HCID 15407842, compound → HCID 15407843, compound

Participants

Reaction Steps

Under an inert atmosphere, 1 mmol of 6-chloro-5-aza-7,12-dioxabenz[a]anthracene and 8 mmol of powdered zinc are brought to 50° C. in 5 ml of acetic acid for 8 hours. After cooling, the reaction mixture is diluted in methanol and then filtered through Celite. The residue is concentrated under vacuum, then washed with saturated sodium hydrogen carbonate solution and then extracted with chloroform. The organic phase is dried over magnesium sulfate and concentrated under vacuum. The crude mixture is chromatographed by flash chromatography on silica gel (eluent: ethyl acetate/petroleum ether).

Provenance & Evidence