反应详情

12.5 g of aluminum trichloride are added to a mixture of 4.27 g of acetyl chloride and 7.5 g of ethyl 1,4-benzodioxin-2-carboxylate in 150 ml of carbon disulfide at 0° C. The reaction mixture is stirred at room temperature for 14 hours. After acid hydrolysis with 50 ml of hydrochloric acid (2N) and extraction of the aqueous phase with dichloromethane, the organic phase is washed with saturated sodium hydrogen carbonate solution and then dried over magnesium sulfate. The acylated product is purified by chromatography on silica gel (eluent: petroleum ether/ethyl acetate, 7:3).

1. customAfter acid hydrolysis
2. extractionwith 50 ml of hydrochloric acid (2N) and extraction of the aqueous phase with dichloromethane
3. washthe organic phase is washed with saturated sodium hydrogen carbonate solution
4. dry with materialdried over magnesium sulfate
5. customThe acylated product is purified by chromatography on silica gel (eluent: petroleum ether/ethyl acetate, 7:3)