反应详情

Under an inert atmosphere, 6 g of ethyl 6-acetoxy-2,3-dibromo- 1,4-benzodioxane-2-carboxylate in solution in 100 ml of acetone are mixed with 7.75 g of potassium iodide and stirred for 6 hours. After evaporation of the acetone under reduced pressure, the residue is diluted in ether and then washed with 20% sodium thiosulfate solution until the mixture is decolorized. The organic phase is then dried over magnesium sulfate and thereafter concentrated under vacuum. The compound is purified by chromatography on silica gel (eluent: petroleum ether/ethyl acetate, 7:3).

1. customAfter evaporation of the acetone under reduced pressure
2. additionthe residue is diluted in ether
3. washwashed with 20% sodium thiosulfate solution until the mixture
4. dry with materialThe organic phase is then dried over magnesium sulfate
5. concentrationconcentrated under vacuum
6. customThe compound is purified by chromatography on silica gel (eluent: petroleum ether/ethyl acetate, 7:3)