Sulfuric Acid → Isopropanol hydrochloride

Participants

Reaction Steps

6-Nitro-1-aminoindane hydrochloride 1-Aminoindane (10.0 g, 75.08 mmol) was added to concentrated sulfuric acid (40 ml) at 0° C. The mix was warmed to room temperature to aid in solvation then cooled to 0° C. Potassium nitrate (7.60 g, 75.08 mmol) was then added portionwise and the mixture allowed to stir at room temperature for 1 hr before being dumped onto ice/50% NaOH. The aqueous solution was extracted with chloroform (3×100 ml). The combined extracts were washed with water, decolorized with charcoal, dried over magnesium sulfate, filtered, and concentrated to an oil. Treatment with IPA/HCl afforded the sub-titled compound: (6.90 g, 43%); m.p. dec 280° C.

Provenance & Evidence