Acetic acid--water (1/1) → HCID 23298398, compound

Participants

Reaction Steps

To 7-nitro-2-(((3-chlorophenyl)methyl)amino)1,2,3,4-tetrahydronaphthalene hydrochloride (1.34 g, 3.80 mmol) in 85% AcOH/H2O (75 ml) was added zinc metal (2.48 g, 38.0 mmol). The mixture was stirred for 5 min. filtered through celite. and evaporated to an oil. The oil was dumped into basic water and extracted with chcloroform (3×20 ml). The combined extracts were washed with water, dried over MgSO4, filtered and concentrated to an oil. Treatment with IPA/HCl yielded 7-amino-2-(((3-chlorophenyl)methyl)amino)1,2,3,4-tetrahydronaphthalene (1.4 g, 99%); M.S. (M+H)+ =288.

Provenance & Evidence