Tetrahydrofuran → HCID 70103189, compound

Participants

Reaction Conditions

Reaction Steps

7.94 g of the product obtained in Stage C above is introduced at ambient temperature into 80 cm3 of anhydrous THF, followed by cooling down to -78° C. and 13.75 cm3 of a 1.6M n-butyllithium solution in hexane is added. After 10 minutes, 15 cm3 of ethyl chloroformate is added, followed by agitation for another 15 minutes at -78° C. 60 cm3 of water is added, the reaction medium is left to return to ambient temperature, the THF is evaporated off, 10 cm3 of 32% soda is added to destroy the excess ethyl chloroformate, followed by extraction with 3×200 cm3 of AcOEt, washing with 2×80 cm3 of water, drying, filtering and evaporating.

Provenance & Evidence