Ethyl Acetate → HCID 86753105, compound

Participants

Reaction Steps

A mixture of 43 (5.3 g, 18.9 mmol), 10% w/w Pd/C (320 mg), ethyl acetate (30 mL), and CH2Cl2 (10 mL) was hydrogenated in a Parr hydrogenation apparatus for 3 h at 45 psi. The mixture was filtered through Celite and concentrated, and the residue was chromatographed on silica gel (ethyl acetate) to afford 44 (4.3 g, 80%). 13C NMR (CDCl3) δ 177.64 (C), 83.87 (CH), 77.21 (CH), 76.02 (CH), 53.45 (CH), 43.84 (CH), 42.96 (CH), 40.46 (CH2), 35.88 (CH), 31.37 (CH2), 29.23 (CH2), 29.10 (CH2), 27.85 (CH2), 26.41 (CH), 26.22 (CH2), 26.08 (CH2).

Provenance & Evidence