p-Toluenesulfonic acid → HCID 86753106, compound

Participants

Reaction Steps

To a mixture of 44 (3.7 g, 12.9 mmol), DHP (2.9 g, 35 mmol), and CH2 Cl2 (80 mL) at 0° C. was added pTSA (300 mg, 1.58 mmol). After 30 min 50 mL of saturated NaHCO3 was added, the layers were separated, the aqueous layer was extracted with CH2CL2 (2×50 mL), the combined organic layers were dried over MgSO4, filtered, and concentrated, and the residue was chromatographed on silica gel (1/1 hexane/ethyl acetate) to afford bis-THP ether 45 (4.89 g, 89%).

Provenance & Evidence