Formic Acid → HCID 18976443, compound

Participants

Reaction Steps

As in example 6g, 2-amino-5-ethoxy-8-methoxytetralin 408 mg (1.84 mmol) in 20 ml THF, was formylated with 360 mg (2.21 mmol) carbonyl dimidazole in 10 ml THF and 102 mg (2.21 mmol) formic acid in 3 ml THF. After stirring overnight, tlc analysis (silica gel; 10:90 CH3OH:CH2Cl2) indicated a major component, Rf 0.53, and absence of starting amine, Rf 0.06. The residue obtained on removal of solvent was dissolved in ethyl acetate, washed with 3N HCl, Na2CO3 solution, brine and dried (MgSO4). Filtration and removal of solvent in vacuo left an off-white solid, 460 mg (100%).

Provenance & Evidence