HCID 18665136, compound → HCID 9815386, compound

Participants

Reaction Steps

It is contemplated that (-)-N-methyl-(2S)-2-amino-8-methoxytetralin can be prepared as follows: (-)(2S)-2-benzylamino-8-methoxytetralin (prepared as described in Karlsson et al., Acta Chemica Scandinavica 1988, B42, 231-236) can be hydrogenated in a Parr apparatus in the presence of 10% palladium on carbon to afford (-)(2S)-2-amino-8-methoxy-tetralin. (-)(2S)-2-Amino-8-methoxytetralin can then be formylated as described in Example 6(g) to afford (-)-N-formyl-(2S)-2-amino-8-methoxytetralin which in turn can be reduced as described in Example 6 to afford (-)-N-methyl-(2S)-2-amino-8-methoxytetralin.

Provenance & Evidence