Hydrochloric Acid → HCID 86753110, compound

Participants

Reaction Conditions

Reaction Steps

Under ice cooling, a hydrochloric acid gas was passed through a stirred solution of 6.79 g of ethyl 3-[3-(2-t-butoxycarbonyl-1,2,3,4-tetrahydro-3-isoquinolinyl)-carbonylamino-2,3-dihydro-2-oxo-1-pentyl-1H-indol-3-yl]-propionate in ethyl acetate (75 ml) until the gas was saturated. The mixture was stirred at 0° C. for 2.5 hours. After removal of solvent, the residue was triturated in isopropyl ether to afford 6.05 g of ethyl 3-[2,3-dihydro-2-oxo-1-pentyl-3-(1,2,3,4-tetrahydro-3-isoquinolinyl)-carbonylamino-1H-indol-3-yl]propionate hydrochloride as a pale yellow amorphous solid. IR (Nujol) (cm-1): 3180, 1725, 1690, 1610, FAB-MS (m/z): 478 (MH+), 132 (base).

Provenance & Evidence