Sodium Hydroxide → HCID 86753113, compound

Participants

Reaction Steps

A mixture of 4.21 ml of 1N sodium hydroxide, 1.80 g of (+)-methyl 3-{1-(4-fluorophenyl)-2,3-dihydro-3-[(3-isoquinolinyl)carbonylamino]-6-methoxy-2-oxo-1H-indol-3-yl}propionate, and ethanol (20 ml) was stirred at room temperature overnight. After removal of solvent, the residue was purified by a nonionic adsorption resin (trade name: HP-20, produced by Mitsubishi Kasei Corporation) to afford 1.64 g of (+)-sodium 3-{1-(4-fluorophenyl)-2,3-dihydro-3-[(3-isoquinolinyl)carbonylamino]-6-methoxy-2-oxo-1H-indol-3-yl}propionate as a colorless powder. [α]D25 : +72.94° (c=0.414, methanol).

Provenance & Evidence