Dimethyl Sulfoxide → HCID 18976173, compound

Participants

Reaction Steps

Under argon gas atmosphere, 29.90 ml of acrylonitrile and 62.70 g of potassium carbonate were added to 210 ml of a dimethyl sulfoxide solution of 70.00 g of 3-amino-1-(2-fluorophenyl)-2,3-dihydro-6-methoxy-1H-indol-2-one hydrochloride, and the whole was stirred at room temperature overnight. The reaction mixture was poured into water, and extracted with ethyl acetate. The ethyl acetate extract was washed with water successively with water and a saturated sodium chloride solution, and dried over anhydrous sodium sulfate and then filtered. The filtrate was evaporated to afford 70.70 g of 3-[3-amino-1-(2-fluorophenyl)-2,3-dihydro-6-methoxy-2-oxo-1H-indol-3-yl]propanenitrile as a brown oil.

Provenance & Evidence