Water → HCID 86753114, compound

Participants

Reaction Steps

1.74 g of potassium carbonate, 5 ml of water and 20 ml of acetonitrile were added to 11.47 g of (+)-3-[1-(2-fluorophenyl)-2,3-dihydro-3-(3-isoquinolinyl)carbonylamino-6-methoxy-2-oxo-1H-indol-3-yl]propionic acid. After removal of solvent under reduced pressure, the residue was dissolved in 100 ml of acetonitrile was added to the residue under heating, and insolubles were filtered off. The filtrate was concentrated, and the residue was dissolved in 100 ml of acetonitrile under heating. After cooling, precipitated crystals were collected by filtration to afford 10.91 g of (+)-potassium 3-[1-(2-fluorophenyl)-2,3-dihydro-3-(3-isoquinolinyl)carbonylamino-6-methoxy-2-oxo-1H-indol-3-yl]-propionate as a colorless solid. Melting point 275° to 277° C. (decomposed). FAB-MS (m/z): 576 (MK+), 538 (MH+), 192, 39 (base). [α]D25 : +91.8° (c=0.438, methanol).

Provenance & Evidence