1,1'-Carbonyldiimidazole → HCID 18976548, compound

Participants

Reaction Steps

Analogously to Example 1, 165.43 g (1.02 mol) of 1,1'-carbonyldiimidazole and 700 ml of tetrahydrofuran are introduced into an apparatus, allowed to react with 202.86 g (1.0 mol) of 3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)propionic acid and subsequently reacted with 107.21 g (1.02 mol) of 2-aminoacetaldehyde dimethyl acetal. The reaction mixture is evaporated to dryness at 80° C./0.1 mbar in a rotary evaporator, and the resultant residue is purified analogously to Example 1, giving 154.2 g (54.2% of theory) of N-(2,2-dimethoxyethyl)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)propionamide, which melts at 123° C.

Provenance & Evidence