Acetic Anhydride → HCID 18665153, compound

Participants

Reaction Steps

To a solution of 2-(trimethyl silyl)ethyl 3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside (compound 14, 8.0 g, 13.6 m mol) in pyridine (40 ml), was added acetic anhydride (10 ml) at 0° C., and the mixture was stirred for 5 hrs at room temperature, and concentrated. Column chromatography (1:2 ethyl acetate-hoxane) of the residue on silica gel (200 g) gave compound 15 (8.6 g, quantitative yield) as crystals:

Provenance & Evidence