Acetonitrile → Faropenem Related Compound 1

Participants

Reaction Steps

15 ml of acetonitrile, 15 ml of toluene and 0.8 g of copper (I) oxide (5.6 mmol) were added to (3S,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-phenylthio-2-azetidinone (2.7 g, 8.0 mmol), and (2R)-tetrahydrofuran-2-thiocarboxylic acid (1.2 g, 9.1 mmol) was added dropwise into the resulting mixture at 10° C. while being stirred.

Provenance & Evidence