Succinic anhydride → HCID 18977141, compound

HRID 2393734Notes

Reaction equation

HRID 2393734 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[CH3:5][CH:6]([CH2:14][CH2:15][N:16]1[C:20](=[O:21])[C:19]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:18]2[C:17]1=[O:26])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[C:27]1(=[O:33])[O:32][C:30](=[O:31])[CH2:29][CH2:28]1>ClC(Cl)C>[CH3:5][CH:6]([CH2:14][CH2:15][N:16]1[C:17](=[O:26])[C:18]2=[CH:25][CH:24]=[CH:23][CH:22]=[C:19]2[C:20]1=[O:21])[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([C:27](=[O:33])[CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 7922Succinic anhydrideHCID 6451240Aluminum(III) ChlorideHCID 18977190HCID 18977190, compound

Product 1

HCID 18977141HCID 18977141, compound

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

Under ice cooling, 24.86 g of anhydrous aluminum chloride was added to a dichloroethane suspension (250 ml) containing of [2-methyl-4-phthalimidobutyl]benzene and 9.29 g of succinic anhydride, and the mixture was stirred temperature for 2 hours. The reaction mixture was poured into ice water, and the organic layer was collected by separation. After the organic layer was washed with water and dried, the solvent was removed. The resulting crude crystal was recrystallized from ethyl acetate-hexane to obtain 16.11 g of 4-(2-methyl-4-phthalimidobutyl)-1-(3-hydroxycarbonylpropionyl)benzene.

Workup

  1. customthe organic layer was collected by separation
  2. washAfter the organic layer was washed with water
  3. customdried
  4. customthe solvent was removed
  5. customThe resulting crude crystal was recrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-07ccfc012a1e4841b2756a13dc88c959
Source dataset
uspto-grants-1998_09
Patent number
US05808065

Reaction notes

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