HCID 18977173, compound → HCID 18977140, compound

HRID 2393741Notes

Reaction equation

HRID 2393741 reaction equation
I([O-])(=O)(=O)=[O:2].[Na+].[CH3:7][S:8][CH2:9][CH2:10][S:11]([NH:14][CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27](=[O:30])[NH:28][N:29]=2)=[CH:20][CH:19]=1)(=[O:13])=[O:12]>C(O)(=O)C>[CH3:7][S:8]([CH2:9][CH2:10][S:11]([NH:14][CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27](=[O:30])[NH:28][N:29]=2)=[CH:20][CH:19]=1)(=[O:13])=[O:12])=[O:2]

Participants

4

Reactant 2

HCID 18977173HCID 18977173, compoundHCID 23667635Sodium periodate

Product 1

HCID 18977140HCID 18977140, compoundYield 89.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

An aqueous solution (25 ml) containing 3.20 g of sodium metaperiodate was added dropwise to an acetic acid suspension (100 ml) containing 5.36 g of 6-[4-(3-(2-methylthioethyl)sulfonylaminopropyl)phenyl]pyridazin-3(2H)-one, and the mixture was stirred at room temperature for 1.5 hours. The reaction mixture was poured into ice water, and precipitated crystal was collected by filtration and dried to obtain 5.00 g of 6-[4-(3-(2-methylsulfinylethyl)sulfonylaminopropyl)phenyl]pyridazin-3(2H)-one.

Workup

  1. customprecipitated crystal
  2. filtrationwas collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-4e403e8662bb4f3d8f8b1187d002cdd1
Source dataset
uspto-grants-1998_09
Patent number
US05808065

Reaction notes

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