HCID 18977140, compound → HCID 18977152, compound

HRID 2393742Notes

Reaction equation

HRID 2393742 reaction equation
CS([CH2:4][CH2:5][S:6]([NH:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:20]=[CH:21][C:22](=[O:25])[NH:23][N:24]=2)=[CH:15][CH:14]=1)(=[O:8])=[O:7])=O>C(O)CO>[CH:5]([S:6]([NH:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:20]=[CH:21][C:22](=[O:25])[NH:23][N:24]=2)=[CH:15][CH:14]=1)(=[O:7])=[O:8])=[CH2:4]

Participants

3

Reactant 1

HCID 18977140HCID 18977140, compound

Product 1

HCID 18977152HCID 18977152, compoundYield 77.5%

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Conditions

Temperature
180 °C

Procedure

An ethylene glycol solution (25 ml) containing 2.48 g of 6-[4-(3-(2-methylsulfinylethyl)sulfonylaminopropyl)phenyl]pyridazin-3(2H)-one was stirred at 180° C. for 1 hour. The reaction mixture was poured into ice water, and precipitated crystal was collected by filtration, washed with water, dried and then recrystallized from methanol to obtain 1.60 g of 6-[4-(3-vinylsulfonylaminopropyl)phenyl]-pyridazin-3(2H)-one.

Workup

  1. customprecipitated crystal
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. customdried
  5. customrecrystallized from methanol

Sources & evidence

ORD record
ord-98c35efdaaa640f4bb82da0077f352d3
Source dataset
uspto-grants-1998_09
Patent number
US05808065

Reaction notes

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