Nicotinic Acid → HCID 18977151, compound

HRID 2393745Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH2:14][CH2:15][C:16](=[O:19])[NH:17][N:18]=2)=[CH:9][CH:8]=1.[C:20](O)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[N:23][CH:22]=1>>[N:23]1[CH:24]=[CH:25][CH:26]=[C:21]([C:20]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[CH2:14][CH2:15][C:16](=[O:19])[NH:17][N:18]=3)=[CH:9][CH:8]=2)=[O:27])[CH:22]=1

Participants

Reactant 2

HCID 938Nicotinic Acid

HCID 18977148HCID 18977148, compound

Product 1

HCID 18977151HCID 18977151, compound

Procedure

By treating 6-[4-(5-aminopentyl)phenyl]-4,5-dihydropyridazin-3(2H)-one and nicotinic acid in the same manner as in Example 30, 6-[4-(5-(pyridin-3-ylcarbonylamino)pentyl)phenyl]-4,5-dihydropyridazin-3(2H)-one was obtained.

Sources & evidence

ORD record: ord-386f0d8662f64bbcb0be3fdd897bfca4
Source dataset: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05808065

Reaction notes

Loading…