Ammonium formate → HCID 18977172, compound

Participants

Reaction Steps

1.0 g of 10% palladium carbon (Pd/C) and 9.0 g of ammonium formate were added to a methanol solution (100 ml) containing 2.0 g of 6-[2-chloro-5-(4-aminobutyl)phenyl]-4,5-dihydropyridazin-3(2H)-one. The resulting suspension was refluxed under heating for 12 hours. The suspension was left to stand for cooling and then filtered, and the filtrate was removed. The residue was purified by silica gel column chromatography (eluent: chloroform-methanol-28% aqueous ammonia (50:10:1)) to obtain 1.3 g of 6-[5-(4-aminobutyl)phenyl]-4,5-dihydropyridazin-3(2H)-one.

Provenance & Evidence