HCID 9798400, compound → HCID 18977165, compound

HRID 2393749Notes

Reaction equation

HRID 2393749 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[CH:22][C:23](=[O:26])[NH:24][N:25]=3)=[CH:16][CH:15]=2)=[O:8])[CH:2]=1.[ClH:27].C(O)C>C(O)C>[ClH:27].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[CH:22][C:23](=[O:26])[NH:24][N:25]=3)=[CH:16][CH:15]=2)=[O:8])[CH:2]=1

Participants

4

Reactant 2

HCID 9798400HCID 9798400, compoundHCID 21887872Ethanol hydrochloride

Product 1

HCID 18977165HCID 18977165, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In hot ethanol (180 ml) was dissolved 8.9 g of 6-[4-(4-(pyridin-3-ylcarbonylamino)butyl)phenyl]pyridazin-3(2H)-one. A 18% hydrochloric acid-ethanol solution (10 ml) was added to the solution, and the mixture was left to stand at room temperature. Precipitated crystal was collected by filtration and washed with cold ethanol to obtain 9.3 g of 6-[4-(4-(pyridin-3-ylcarbonylamino)butyl)phenyl]pyridazin-3(2H)-one hydrochloride.

Workup

  1. waitthe mixture was left
  2. customto stand at room temperature
  3. customPrecipitated crystal
  4. filtrationwas collected by filtration
  5. washwashed with cold ethanol

Sources & evidence

ORD record
ord-5863711c96ab4d5488285f496ae817ee
Source dataset
uspto-grants-1998_09
Patent number
US05808065

Reaction notes

Loading…