2-Chloropropionyl chloride → HCID 18977161, compound

HRID 2393751Notes

Reaction equation

HRID 2393751 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[C:5]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:7])[CH3:6].[Cl:19][CH:20]([CH3:24])[C:21](Cl)=[O:22]>ClC(Cl)C>[C:5]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:14]=[CH:15][C:16]([C:21](=[O:22])[CH:20]([Cl:19])[CH3:24])=[CH:17][CH:18]=1)(=[O:7])[CH3:6]

Participants

5

Reactant 3

HCID 1110192-Chloropropionyl chlorideHCID 605592HCID 605592, compoundHCID 6451240Aluminum(III) Chloride

Product 1

HCID 18977161HCID 18977161, compoundYield 93.1%

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Conditions

Temperature
5 °C

Procedure

Under ice cooling, 20.9 g of anhydrous aluminum chloride was added to 200 ml of a dichloroethane solution containing 10.0 g of [4-(acetylamino)butyl]benzene and 9.96 g of 2-chloropropionyl chloride, and the mixture was stirred at 5° C. for 1 hour. The reaction mixture was poured into ice water, and the organic layer was collected by separation. After the organic layer was washed with water and dried, the solvent was removed to obtain 13.71 g of 4-[4-(acetylamino)butyl]-1-(2-chloropropionyl)benzene.

Workup

  1. customthe organic layer was collected by separation
  2. washAfter the organic layer was washed with water
  3. customdried
  4. customthe solvent was removed

Sources & evidence

ORD record
ord-eae1fda14cc64f0ea78faa5b1964fff1
Source dataset
uspto-grants-1998_09
Patent number
US05808065

Reaction notes

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