3-ethylisoxazole-5-carboxylic acid → HCID 21465238, compound

HRID 2393757Notes

Reaction equation

HRID 2393757 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[NH:16][N:17]=2)=[CH:8][CH:7]=1.[CH2:19]([C:21]1[CH:25]=[C:24]([C:26](O)=[O:27])[O:23][N:22]=1)C>>[CH3:19][C:21]1[CH:25]=[C:24]([C:26]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]2[CH:7]=[CH:8][C:9]([C:12]3[CH:13]=[CH:14][C:15](=[O:18])[NH:16][N:17]=3)=[CH:10][CH:11]=2)=[O:27])[O:23][N:22]=1

Participants

3

Reactant 2

HCID 64842773-ethylisoxazole-5-carboxylic acidHCID 18977179HCID 18977179, compound

Product 1

HCID 21465238HCID 21465238, compound

Procedure

By treating 6-[4-(4-aminobutyl)phenyl]pyridazin-3(2H)-one and 3-ethyl-5-carboxyisoxazole in the same manner as in Example 87, 6-{4-[4-(3-methylisoxazole-5-ylcarbonylamino) butyl]phenyl}pyridazin-3(2H)-one was obtained.

Sources & evidence

ORD record
ord-cda77f54df854686b05ecaf49a2304cd
Source dataset
uspto-grants-1998_09
Patent number
US05808065

Reaction notes

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