Water → HCID 178460354, compound

HRID 2393759Notes

Reaction equation

HRID 2393759 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].O.[C:14]([C:22]1[CH:23]=[C:24]([CH:28]([CH3:32])[C:29]([OH:31])=[O:30])[CH:25]=[CH:26][CH:27]=1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CC(C)=O>[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9].[C:14]([C:22]1[CH:23]=[C:24]([CH:28]([CH3:32])[C:29]([OH:31])=[O:30])[CH:25]=[CH:26][CH:27]=1)(=[O:21])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

5

Reactant 3

HCID 962WaterHCID 3825KetoprofenHCID 178418600HCID 178418600, compound

Product 1

HCID 178460354HCID 178460354, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 0.6 g L-arginine in 1 ml boiling water under gentle stirring is added to a solution of 1.02 g of R(-) 2-(3-benzoylphenyl)propionic acid in 10 ml acetone, heated to 40°-45° C.; a solid is separated which is filtered hot gives 1.3 g of R(-) 2-(3-benzoylphenyl)propionic acid L-arginine salt melting at 75° C.

Workup

  1. temperatureheated to 40°-45° C.
  2. customa solid is separated which
  3. filtrationis filtered hot

Sources & evidence

ORD record
ord-1ea4e98dfbd14387b0a40383fd70e2b4
Source dataset
uspto-grants-1998_09
Patent number
US05808069

Reaction notes

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