HCID 15287762, compound → HCID 12219951, compound

HRID 2393767Notes

Reaction equation

HRID 2393767 reaction equation
O[NH:2][C@H:3]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]>C(O)C>[NH2:2]/[C:3](=[CH:4]/[C:5]([O:7][CH2:8][CH3:9])=[O:6])/[C:10]([O:12][CH2:13][CH3:14])=[O:11]

Participants

3

Reactant 1

HCID 15287762HCID 15287762, compound

Product 1

HCID 12219951HCID 12219951, compoundYield 34.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution (10 ml) of diethyl N-hydroxyaspartate (9.4% solution, 7.8 g, 3.6 mmol) in ethanol was fed in a quartz column (1 inch ID) containing glass beads (3 inches long) at 200° C. at the rate of 0.2 ml per minute along with nitrogen at a rate of 1000 ml per minute. The vaporized material escaping at the end of quartz column was collected using a dry-ice trap. The condensate (0.35 g) was analyzed by GLC. The analysis found that the reaction gave diethyl 2-aminomaleate in about 34.5% yield.

Workup

  1. additioncontaining glass beads (3 inches long) at 200° C. at the rate of 0.2 ml per minute along with nitrogen at a rate of 1000 ml per minute
  2. customwas collected

Sources & evidence

ORD record
ord-0be5e99b23c242e3ba25e6598372bdd3
Source dataset
uspto-grants-1998_09
Patent number
US05808067

Reaction notes

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