Methoxyacetic Acid → Methoxyacetic Acid

Participants

Role	Name	HCID	Charge
Reactant	Methoxyacetic Acid	HCID 12251	—
Reactant	2-[2-{[3-(1H-benzimidazol-2-yl)propyl]methylamino}ethyl]-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-ol	HCID 54487328	—
Product	Methoxyacetic Acid	HCID 12251	—
Product	2-methoxyacetic acid [2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] ester	HCID 5230270	—

Reaction Steps

The method of claim 9 further including the step of contacting the thus-formed 2-[2-{[3-(1H-benzimidazol-2-yl)propyl]methylamino}ethyl]-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-ol with methoxyacetic acid or an activated derivative of methoxyacetic acid to form 2-[2-{[3-(1H-benzimidazol-2-yl)propyl]methylamino}ethyl]-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05808088
Source dataset	uspto-grants-1998_09
ORD ID	ord-4d39fee87fa24001b69298582580c42e
Source note	uspto-grants-1998_09