Benzene, [1-[(trimethylsilyl)oxy]ethenyl]- → 4-Hydroxy-3-[(2-isobutylphenyl)thio]-6-phenyl-2H-pyran-2-one
Reaction equation
[C:1]1([C:7]([O:9][Si](C)(C)C)=[CH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:14]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[S:24][CH:25]([C:29](O)=[O:30])[C:26](O)=[O:27])[CH:15]([CH3:17])[CH3:16]>>[OH:30][C:29]1[CH:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[O:9][C:26](=[O:27])[C:25]=1[S:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[CH2:14][CH:15]([CH3:17])[CH3:16]Participants
3
Procedure
The title compound was prepared by Method A using 1-phenyl-1-(trimethylsilyloxy)ethylene (1.96 g, 10.20 mmol) and diethyl ester of [(2-isobutylphenyl)thio]propanedioic acid (1.64 g, 5.1 mmol). m.p. 195° C. 1H NMR (400 MHz, DMSO-d6) δ 0.83 (d, 6H), 1.64 (m, 1H), 2.39 (d, 2H), 6.89 (s, 1H), 7.06 (s, 4H), 7.56 (m, 3H), 7.86 (m, 2H).
Sources & evidence
- ORD record
- ord-08e60e7477ff4bd183c293d561446ce6
- Source dataset
- uspto-grants-1998_09
- Patent number
- US05808062
Reaction notes
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