反应详情

A mixture of 13 parts of 1-(tetrahydro-3,3-diphenyl-2-furylidene) pyrrolidinium bromide, 5.3 parts of 4-phenyl-4-piperidinol 8 parts of sodium carbonate, 0.2 parts of potassium iodide and 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 5 hours with water separator. The reaction mixture is cooled and water is added. The organic layer s separated, washed with diluted sodium hydroxide solution, dried, filtered, and while stirring the filtrate, the product is crystallized. It is filtered off and dried, yielding 1-[4-(4-hydroxy-4-phenylpiperidino)-2,2-diphenylbutyryl]pyrrolidine; m.p. 187.5° C.

1. temperatureThe reaction mixture is cooled
2. customThe organic layer s separated
3. washwashed with diluted sodium hydroxide solution
4. customdried
5. filtrationfiltered
6. stirringwhile stirring the filtrate
7. customthe product is crystallized
8. filtrationIt is filtered off
9. customdried