HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2,4-Bis(trifluoromethyl)pyrimidine-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2,4-bis(trifluoromethyl)pyrimidine-5-carboxylate | HCID 10493558 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,4-Bis(trifluoromethyl)pyrimidine-5-carboxylic acid | HCID 10539242 | 33.9% |
Reaction Steps
A solution of ethyl-2,4-bis(trifluoromethyl)pyrimidine-5-carboxylate (5.0 g, 17 mmol) and NaOH (0.72 g, 18 mmol) in EtOH (20 mL) and H2O (50 mL) was stirred at room temperature for 1 h. The solution was acidified (HCl) and the resulting solid was filtered and dried to give 2,4-bis (trifluoromethyl)-pyrimidine-5-carboxylic acid (1.5 g, 25%), m.p. 59° C., 1HNMR (DMSO-d6) δ 9.62 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05811428 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-bf354a962e6e470eaaf32f7cad0bfba2 |
| Source note | uspto-grants-1998_09 |