HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-Chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic Acid | HCID 10823150 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl chloride | HCID 2736708 | 70% |
Reaction Steps
The title compound was prepared as described in Example 25, but employing a solution of 2-chloro-4-trifluoromethylpyrimidine-5-carboxylic acid (1.5 g, 7.1 mmol) and oxalyl chloride (1.0 g, 8 mmol) in CH2Cl2 (30 mL) resulted in a 70% yield (1.1 g); 1H NMR (CDCl3) δ 9.31 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05811428 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-5557b908d2a645a5b909a7840fbb6120 |
| Source note | uspto-grants-1998_09 |