Water → HCID 18973143, compound

HRID 2394291Notes

Reaction equation

HRID 2394291 reaction equation
[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([C:6](=[O:25])[C:7]([C:20]([O:22]CC)=[O:21])=[CH:8][N:9]2[C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:4][N:3]=1.O.S(=O)(=O)(O)O>C(O)(=O)C>[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([C:6](=[O:25])[C:7]([C:20]([OH:22])=[O:21])=[CH:8][N:9]2[C:13]2[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=2)=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 18973147HCID 18973147, compound

Product 1

HCID 18973143HCID 18973143, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3.3 g (0.0087 mol) of ethyl 7,8-dichloro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylate are heated at reflux in a mixture of 11.5 ml of acetic acid, 11.5 ml of water and 1.15 ml of concentrated sulphuric acid for two hours. The cooled mixture is put into ice-water, the product is isolated and washed with water.

Workup

  1. customthe product is isolated
  2. washwashed with water

Sources & evidence

ORD record
ord-fea17aa3e1c54359945a1b432a64152b
Source dataset
uspto-grants-1998_09
Patent number
US05811433

Reaction notes

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