Acetic Anhydride → HCID 53720853, compound

HRID 2394301Notes

Reaction equation

HRID 2394301 reaction equation
[Cl:1][C:2]1[C:7]([C:8]([CH2:10][C:11]([O-:13])=[O:12])=[O:9])=[C:6]([CH3:14])[N:5]=[C:4]([Cl:15])[C:3]=1[Cl:16].[CH:17]([O-])([O-])[O:18][CH2:19][CH3:20].[C:23](OC(=O)C)(=O)[CH3:24]>>[Cl:1][C:2]1[C:7]([C:8]([C:10](=[CH:17][O:18][CH2:19][CH3:20])[C:11]([O:13][CH2:23][CH3:24])=[O:12])=[O:9])=[C:6]([CH3:14])[N:5]=[C:4]([Cl:15])[C:3]=1[Cl:16]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 53630039EthylorthoformateHCID 86753129HCID 86753129, compound

Product 1

HCID 53720853HCID 53720853, compound

Procedure

29.2 g (0.09 mol) of ethyl 2-(4,5,6-trichloro-2-methyl-nicotinoyl-acetate are heated with 20.9 g (0.141 mol) of ethyl orthoformate and 23.9 g (0.23 mol) of acetic anhydride at 150°-160° C. for two hours. All volatile components are removed, initially in vacuo and then under a high vacuum up to 80° C.

Workup

  1. customAll volatile components are removed, initially in vacuo
  2. customup to 80° C.

Sources & evidence

ORD record
ord-d40c487a442341af977621b3441d0ae9
Source dataset
uspto-grants-1998_09
Patent number
US05811433

Reaction notes

Loading…