Cyclopropylamine → HCID 178471884, compound

HRID 2394302Notes

Reaction equation

HRID 2394302 reaction equation
[Cl:1][C:2]1[C:7]([C:8]([C:10](=[CH:16]OCC)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[C:6]([CH3:20])[N:5]=[C:4]([Cl:21])[C:3]=1[Cl:22].[CH:23]1([NH2:26])[CH2:25][CH2:24]1>C(O)C>[Cl:1][C:2]1[C:7]([C:8]([C:10](=[CH:16][NH:26][CH:23]2[CH2:25][CH2:24]2)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[C:6]([CH3:20])[N:5]=[C:4]([Cl:21])[C:3]=1[Cl:22]

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 53720853HCID 53720853, compound

Product 1

HCID 178471884HCID 178471884, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

27 g (0.07 mol) of ethyl 2-(4,5,6-trichloro-2-methyl-nicotinoyl)-3-ethoxyacrylate are placed at 0° C. in 93 ml of ethanol, and 4.3 g (0.07 mol) of cyclopropylamine in 34 ml of ethanol are added dropwise. The mixture is stirred at room temperature for thirty minutes and cooled to 0° C. and the product which precipitates is isolated and washed with cold ethanol.

Workup

  1. temperaturecooled to 0° C.
  2. customthe product which precipitates
  3. customis isolated
  4. washwashed with cold ethanol

Sources & evidence

ORD record
ord-4a947f0ab0034781988d3acaee963ad0
Source dataset
uspto-grants-1998_09
Patent number
US05811433

Reaction notes

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