HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S,6S)-2,8-Diazabicyclo(4.3.0)nonane → HCID 18665331, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S,6S)-2,8-Diazabicyclo(4.3.0)nonane | HCID 10313138 | — |
| Reactant | 7,8-Dichloro-1-cyclopropyl-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid | HCID 18973121 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 18665331 | HCID 18665331 | — |
Reaction Steps
200 mg (0.67 mmol) of 7,8-dichloro-1-cyclopropyl-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid are stirred with 190 mg (1.5 mmol) of (1S,6S)-2,8-diazabicyclo[4.3.0]nonane in a mixture of 1.7 ml of dimethylformamide and 1.7 ml of acetonitrile under argon overnight. The precipitate is isolated and washed with acetonitrile. The crude product is purified on silica gel (eluent: dichloromethane/methanol/aqueous ammonia solution 75:20:25).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05811433 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-3937b85528af4856a326fae06cced6c6 |
| Source note | uspto-grants-1998_09 |