HCID 10624338, compound → HCID 10806764, compound

Participants

Reaction Steps

A mechanically stirred mixture of 2-bis(benzyloxycarbonyl)methyl-3-nitro-5-trifluoromethylpyridine (1.2 g, 2.5 mmol), iron dust (495 mg, 8.9 mmol), and glacial acetic acid (50 mL) was heated at reflux for 2 hr. After cooling, the mixture was poured into ice/water. The precipitated white solid was collected by filtration, air-dried and then dried in vacuo overnight. Yield: 780 mg (93%); mp>250° C.

Provenance & Evidence