alpha-Bromo-o-fluorotoluene → HCID 17221159, compound

HRID 2394403Notes

Reaction equation

HRID 2394403 reaction equation
[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=[O:11])[C:4]=2[CH:3]=[CH:2]1.[F:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15]Br>>[F:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][N:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=[O:11])[C:4]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 67968alpha-Bromo-o-fluorotolueneHCID 333703Indole-4-carboxaldehyde

Product 1

HCID 17221159HCID 17221159, compound

Procedure

The same procedures used in Example 1 were repeated except for using 725 mg of indole-4-carbaldehyde and 2-fluorobenzyl bromide instead of the benzyl bromide used in Example 1 to give 1.22 g of 1-(2-fluorobenzyl)indole-4-carbaldehyde as yellow crystals. The yield thereof was found to be 96%.

Sources & evidence

ORD record
ord-c1795ac24553471a9faa37afe8428b3f
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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