Indole-4-carboxaldehyde → HCID 18973470, compound

HRID 2394406Notes

Reaction equation

HRID 2394406 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4]Cl.[NH:11]1[C:19]2[CH:18]=[CH:17][CH:16]=[C:15]([CH:20]=[O:21])[C:14]=2[CH:13]=[CH:12]1>>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4][N:11]1[C:19]2[CH:18]=[CH:17][CH:16]=[C:15]([CH:20]=[O:21])[C:14]=2[CH:13]=[CH:12]1

Participants

3

Reactant 2

HCID 333703Indole-4-carboxaldehydeHCID 5815702,6-Difluorobenzyl chloride

Product 1

HCID 18973470HCID 18973470, compoundYield 100.1%

Procedure

The same procedures used in Example 1 were repeated except for using 2.35 g of 2,6-difluorobenzyl chloride and 2.00 g of indole-4-carbaldehyde as a starting material to give 3.74 g of 1-(2,6-difluorobenzyl)indole-4-carbaldehyde as pale yellow crystals. The yield thereof was found to be 100%.

Sources & evidence

ORD record
ord-b6c02786dbae4f6fbf47843ab90cdad0
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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