Indole-4-carboxaldehyde → HCID 18973257, compound

HRID 2394409Notes

Reaction equation

HRID 2394409 reaction equation
CS(O[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)(=O)=O.[NH:17]1[C:25]2[CH:24]=[CH:23][CH:22]=[C:21]([CH:26]=[O:27])[C:20]=2[CH:19]=[CH:18]1>>[F:14][C:13]([F:16])([F:15])[C:9]1[CH:8]=[C:7]([CH:12]=[CH:11][CH:10]=1)[CH2:6][N:17]1[C:25]2[CH:24]=[CH:23][CH:22]=[C:21]([CH:26]=[O:27])[C:20]=2[CH:19]=[CH:18]1

Participants

3

Reactant 2

HCID 333703Indole-4-carboxaldehydeHCID 11118600HCID 11118600, compound

Product 1

HCID 18973257HCID 18973257, compoundYield 98.6%

Procedure

The same procedures used in Example 1 were repeated except for using 3.68 g of 3-trifluoromethylbenzyl methanesulfonate and 2.00 g of indole-4-carbaldehyde to give 4.12 g of 1-(3-trifluoromethylbenzyl) indole-4-carbaldehyde as yellow crystals. The yield thereof was found to be 99%.

Sources & evidence

ORD record
ord-139d39d7517e4445b48def2589345ef1
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

Loading…