Indole-4-carboxaldehyde → HCID 18973526, compound

HRID 2394412Notes

Reaction equation

HRID 2394412 reaction equation
[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=[O:11])[C:4]=2[CH:3]=[CH:2]1.CS(O[CH2:17][C:18]1[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[CH:20][C:19]=1[O:26][CH3:27])(=O)=O>>[CH3:27][O:26][C:19]1[CH:20]=[CH:21][C:22]([O:24][CH3:25])=[CH:23][C:18]=1[CH2:17][N:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=[O:11])[C:4]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 333703Indole-4-carboxaldehydeHCID 18973531HCID 18973531, compound

Product 1

HCID 18973526HCID 18973526, compound

Procedure

The same procedures used in Example 1 were repeated except for using 725 mg of indole-4-carbaldehyde and 2,5-dimethoxybenzyl methanesulfonate instead of the benzyl bromide used in Example 1 to give 940 mg of 1-(2,5-dimethoxybenzyl)indole-4-carbaldehyde as pale yellow crystals. The yield thereof was found to be 64%.

Sources & evidence

ORD record
ord-b20d6bd64885486489692aa7ab9bb02f
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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