Indole-4-carboxaldehyde → HCID 18973572, compound

HRID 2394420Notes

Reaction equation

HRID 2394420 reaction equation
CS(O[CH2:6][CH2:7][N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)(=O)=O.[NH:13]1[C:21]2[CH:20]=[CH:19][CH:18]=[C:17]([CH:22]=[O:23])[C:16]=2[CH:15]=[CH:14]1>>[N:8]1([CH2:7][CH2:6][N:13]2[C:21]3[CH:20]=[CH:19][CH:18]=[C:17]([CH:22]=[O:23])[C:16]=3[CH:15]=[CH:14]2)[CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 333703Indole-4-carboxaldehydeHCID 13174334HCID 13174334, compound

Product 1

HCID 18973572HCID 18973572, compoundYield 32.3%

Procedure

The same procedures used in Example 154 were repeated except for using 5.32 g of N-(2-methanesulfonyloxyethyl)pyrrolidine and 2.00 g of indole-4-carbaldehyde as a starting material to give 1.08 g of 1-[2-(pyrrolidin-1-yl)ethyl]indole-4-carbaldehyde as a yellow oily substance. The yield thereof was found to be 33%.

Sources & evidence

ORD record
ord-197438a62c184879bc7114daa2020129
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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