4-Nitrobenzyl bromide → HCID 18973553, compound

HRID 2394425Notes

Reaction equation

HRID 2394425 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Br)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:12]1[C:20]2[CH:19]=[CH:18][CH:17]=[C:16]([CH:21]=[O:22])[C:15]=2[CH:14]=[CH:13]1>>[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][N:12]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([CH:21]=[O:22])[C:15]=3[CH:14]=[CH:13]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 660114-Nitrobenzyl bromideHCID 333703Indole-4-carboxaldehyde

Product 1

HCID 18973553HCID 18973553, compoundYield 55.4%

Procedure

The same procedures used in Example 7 were repeated except for using 4.46 g of 4-nitrobenzyl bromide and 2.00 g of indole-4-carbaldehyde as a starting material to give 2.14 g of 1-(4-nitrobenzyl) indole-4-carbaldehyde as an orange-colored oily substance. The yield thereof was found to be 59%.

Sources & evidence

ORD record
ord-482c4623377b4effaf66214674b40b21
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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