Indole-4-carboxaldehyde → HCID 18973282, compound

HRID 2394426Notes

Reaction equation

HRID 2394426 reaction equation
CS(O[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:8]=1[O:15][CH3:16])(=O)=O.[NH:17]1[C:25]2[CH:24]=[CH:23][CH:22]=[C:21]([CH:26]=[O:27])[C:20]=2[CH:19]=[CH:18]1>>[CH3:16][O:15][C:8]1[CH:9]=[C:10]([O:13][CH3:14])[CH:11]=[CH:12][C:7]=1[CH2:6][N:17]1[C:25]2[CH:24]=[CH:23][CH:22]=[C:21]([CH:26]=[O:27])[C:20]=2[CH:19]=[CH:18]1

Participants

3

Reactant 2

HCID 333703Indole-4-carboxaldehydeHCID 18973538HCID 18973538, compound

Product 1

HCID 18973282HCID 18973282, compoundYield 24.7%

Procedure

The same procedures used in Example 1 were repeated except for using 2.03 g of 2,4-dimethoxybenzyl methanesulfonate and 2.00 g of indole-4-carbaldehyde as a starting material to give 602 mg of 1-(2,4-dimethoxybenzyl)indole-4-carbaldehyde as a yellow oily substance. The yield thereof was found to be 15%.

Sources & evidence

ORD record
ord-434b8c45da56411784d92aa975dfb83d
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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