Indole-4-carboxaldehyde → HCID 18973378, compound

HRID 2394429Notes

Reaction equation

HRID 2394429 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]([CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=1)[CH2:6]CS([O-])(=O)=O.[NH:21]1[C:29]2[CH:28]=[CH:27][CH:26]=[C:25]([CH:30]=[O:31])[C:24]=2[CH:23]=[CH:22]1>>[F:20][C:2]([F:1])([F:19])[C:3]1[CH:4]=[C:5]([CH:12]=[C:13]([C:15]([F:16])([F:17])[F:18])[CH:14]=1)[CH2:6][N:21]1[C:29]2[CH:28]=[CH:27][CH:26]=[C:25]([CH:30]=[O:31])[C:24]=2[CH:23]=[CH:22]1

Participants

3

Reactant 2

HCID 333703Indole-4-carboxaldehydeHCID 18973481HCID 18973481, compound

Product 1

HCID 18973378HCID 18973378, compoundYield 82.9%

Procedure

The same procedures used in Example 1 were repeated except for using 4.80 g of [3,5-bis(trifluoromethyl)benzyl]methanesulfonate and 2.00 g of indole-4-carbaldehyde as a starting material to give 4.24 g of 1-[3,5-bis(trifluoromethyl)benzyl]indole-4-carbaldehyde as pale yellow crystals. The yield thereof was found to be 83%.

Sources & evidence

ORD record
ord-d795391f05624456bb602a55a1cded76
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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