2-Bromobenzyl bromide → (2-Bromobenzyl) indole-4-carbaldehyde

HRID 2394431Notes

Reaction equation

HRID 2394431 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[NH:10]1[C:18]2[CH:17]=[CH:16][CH:15]=[C:14]([CH:19]=[O:20])[C:13]=2[CH:12]=[CH:11]1>>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][C:11]1[NH:10][C:18]2[CH:17]=[CH:16][CH:15]=[C:14]([CH:19]=[O:20])[C:13]=2[CH:12]=1

Participants

3

Reactant 2

HCID 769652-Bromobenzyl bromideHCID 333703Indole-4-carboxaldehyde

Product 1

HCID 54532249(2-Bromobenzyl) indole-4-carbaldehydeYield 96.6%

Procedure

The same procedures used in Example 1 were repeated except for using 3.78 g of o-bromobenzyl bromide and 2.00 g of indole-4-carbaldehyde as a starting material to give 4.18 g of (2-bromobenzyl) indole-4-carbaldehyde as pale yellow crystals. The yield thereof was found to be 97%.

Sources & evidence

ORD record
ord-5e57c3860c4940368c999dbc06a6a175
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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