Indole-3-Carboxaldehyde → HCID 18973384, compound

HRID 2394433Notes

Reaction equation

HRID 2394433 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=[O:11])=[CH:2]1.[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=1[F:21])[CH2:16]Br>>[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=1[F:21])[CH2:16][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=[O:11])=[CH:2]1

Participants

3

Reactant 2

HCID 10256Indole-3-CarboxaldehydeHCID 5814364-(Bromomethyl)-1,2-difluorobenzene

Product 1

HCID 18973384HCID 18973384, compound

Procedure

The same procedures used in Example 1 were repeated except for using 870 mg of indole-3-carbaldehyde and 3,4-difluorobenzyl bromide in place of the benzyl bromide used in Example 1 to give 1.59 g of 1-(3,4-difluorobenzyl)indole-3-carbaldehyde as pale brown crystals. The yield thereof was found to be 98%.

Sources & evidence

ORD record
ord-ddc29ec007fb46c580e859eb99b7bc41
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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