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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2394434Generated: October 30, 2026

Indole-3-Carboxaldehyde → 1-(2-fluorobenzyl)-1H-indole-3-carbaldehyde

https://huagongshe.com/reaction/2394434

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIndole-3-CarboxaldehydeHCID 10256—
Reactantalpha-Bromo-o-fluorotolueneHCID 67968—
Product1-(2-fluorobenzyl)-1H-indole-3-carbaldehydeHCID 775586—

Reaction Steps

The same procedures used in Example 1 were repeated except for using 870 mg of indole-3-carbaldehyde and 2-fluorobenzyl bromide in place of the benzyl bromide used in Example 1 to give 1.46 g of 1-(2-fluorobenzyl)indole-3-carbaldehyde as yellowish brown crystals. The yield thereof was found to be 96%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05811439
Source datasetuspto-grants-1998_09
ORD IDord-59f9074edc3d4f36921ba4d2d165be41
Source noteuspto-grants-1998_09