Indole-3-Carboxaldehyde → HCID 819948, compound

HRID 2394437Notes

Reaction equation

HRID 2394437 reaction equation
CS(O[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)(=O)=O.[NH:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19]([CH:26]=[O:27])=[CH:18]1>>[F:14][C:13]([F:16])([F:15])[C:9]1[CH:8]=[C:7]([CH:12]=[CH:11][CH:10]=1)[CH2:6][N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19]([CH:26]=[O:27])=[CH:18]1

Participants

3

Reactant 2

HCID 10256Indole-3-CarboxaldehydeHCID 11118600HCID 11118600, compound

Product 1

HCID 819948HCID 819948, compoundYield 95.2%

Procedure

The same procedures used in Example 1 were repeated except for using 3.68 g of (3-trifluoromethylbenzyl) methanesulfonate and 2.00 g of indole-3-carbaldehyde as a starting material to give 3.98 g of 1-(3-trifluoromethylbenzyl)indole-3-carbaldehyde as pale yellow crystals. The yield thereof was found to be 95%.

Sources & evidence

ORD record
ord-51df6cbabbf0466bbff3f8192edf694b
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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