Indole-3-Carboxaldehyde → HCID 54096697, compound

HRID 2394438Notes

Reaction equation

HRID 2394438 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[NH:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]([CH:19]=[O:20])=[CH:11]1>>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][C:11]2[NH:10][C:18]3[C:13]([C:12]=2[CH:19]=[O:20])=[CH:14][CH:15]=[CH:16][CH:17]=3)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10256Indole-3-CarboxaldehydeHCID 680214-Fluorobenzyl bromide

Product 1

HCID 54096697HCID 54096697, compoundYield 91.1%

Procedure

The same procedures used in Example 1 were repeated except for using 2.74 g of 4-fluorobenzyl bromide and 2.00 g of indole-3-carbaldehyde as a starting material to give 3.18 g of (4-fluorobenzyl) indole-3-carbaldehyde as colorless crystals. The yield thereof was found to be 91%.

Sources & evidence

ORD record
ord-16361189c6424f11b9f7c26d80629715
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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